Inflammation is a physiological response to a variety of agents. Arthritis is a complex autoimmune disease, which causes inflammation.
There are many medicines, which are used in these diseases to control inflammation, which has various side effects. Some of the effects are very serious. The most common are increase in the development of ulcers in stomach and duodenum. Inhibition of uterine mobility and hyper reaction, nausea, vomiting, indigestion, diarrhea, heartburn, headache, dizziness, rapid weight gain and breathing problem.
The long-term use of these medicines for this can cause suppression of pituitary -adrenal gland etc. Biological activities of many plants have been used since ages for the treatment of inflationary diseases. The biological activities are often due to the Essential Oil content in the plants. Essential Oil possesses anti-oxidant, anti-bacterial, anti-fungal and anti-inflammatory properties.
In a research it was found that the subject who were treated with Essential Oils blend had reported significantly reduced severity of arthritis.
The result shows that Essential Oil is the active anti arthritic agent. Use Of Essential Oil blend reduced the level of TNF-α and IL-I β in synovial fluid and SIC lysate. The inhibition of pro-inflammatory cytokines as one of the mechanisms by which Essential Oil mediate the anti arthritic activity.
MMP (Matrix Metallo Proteinase) are extracellular protein degrading protease that damage bone and cartilage in arthritic joints. .Increased level of MMPs in synovial fluid correlate with the release of matrix proteins like Fibronectin.
Suppression of MMPs and pro-inflammatory Cytokines in synovial fluid and SIC helps in controlling bone damage and inflammation during active arthritis. Thus the measurement of the level of pro inflammatory cytokines and the activity of MMPs as well as histological examination of joints support that the tissue damage was suppressed with Essential Oil blend treatment for 7 days twice daily.
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